What question did this study set out to answer?

To explore how multiple regulatory axes interact to maintain electrolyte stability in physiology.

February 19, 2026Open Access

Multi-Axis Regulatory Geometry in Electrolyte Physiology: Integration of Bile Acid Signaling, Renal Execution, and Systemic State, V 1.5, February 2026

Key Points

To explore how multiple regulatory axes interact to maintain electrolyte stability in physiology.
Review and integration of existing literature on bile acid signaling, renal nitric oxide production, and RAAS modulation.
Development of a structural framework for electrolyte physiology including endocrine and systemic factors.
Proposes that electrolyte stability results from the interaction of various regulatory systems, highlighting the role of endocrine and renal factors.
Identifies potential mechanisms through which hyperchloremic acid-base disorders could develop.

Abstract

This mechanistic continuity note extends prior work linking bile acid receptor signaling, renal nitric oxide production, and RAAS modulation to downstream electrolyte regulation. Version 1.5 proposes that electrolyte stability emerges from interaction between multiple regulatory axes, including endocrine signaling, renal integration state, and systemic physiological conditions. This structural framework is hypothesis-generating and intended to support future investigation into integrated electrolyte physiology and hyperchloremic acid–base phenotypes.

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Beth Martell

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Multi-Axis Regulatory Geometry in Electrolyte Physiology: Integration of Bile Acid Signaling, Renal Execution, and Systemic State, V 1.5, February 2026

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Abstract

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