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This research investigates the hormonal and sex-based differences in cue reactivity related to substance use disorders.

February 20, 2026

Beyond Men Versus Women: Ovarian Hormones Shape Cue Reactivity in Substance Use Disorders

Key Points

This research investigates the hormonal and sex-based differences in cue reactivity related to substance use disorders.
Analyzed the impact of ovarian hormones on substance use behavior.
Explored gender differences associated with illicit drug and alcohol consumption.
Emphasized the need for tailored treatment based on hormonal states.
Illicit drug use prevalence is higher among men than women, but the gap is narrowing.
Alcohol consumption rates in women are increasing, complicating treatment needs.
Gender-specific mechanisms play a crucial role in addiction outcomes and treatment approaches.

Abstract

Understanding sex- and hormone-specific mechanisms underlying substance use disorders (SUDs) has become an increasingly essential topic in addiction research and treatment. The prevalence of illicit drug or alcohol use is generally higher in men than in women ( 1 ). However, as this gap appears to be narrowing over recent years e.g., for alcohol consumption ( 2 ) and women are still underrepresented regarding treatment ( 1 ), there is an urgent need for scientific research that not only addresses underlying mechanisms but also informs treatment options. SEE CORRESPONDING ARTICLE ON PAGE 457 SEE CORRESPONDING ARTICLE ON PAGE 457

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