Combined aerobic and resistance exercise training for 8 weeks improved global cognitive functions correlated with reductions in mean blood pressure (r = -0.74), triglycerides (r = -0.52), total cholesterol (r = -0.51), and increased leptin (r = 0.60) in adults with type 2 diabetes.
RCT (n=16)
null
Controlled clinical trial with exercise group only analyzed
No
Are exercise-induced improvements in blood pressure, blood lipids, and glycemic parameters related to global cognitive improvement in people with type 2 diabetes mellitus?
In adults with type 2 diabetes, exercise-induced improvements in global cognitive function are associated with reductions in blood pressure and lipids, but not glycemic parameters.
Effect estimate: Correlations between cognitive function change and risk factor changes: mean blood pressure r = -0.74, triglycerides r = -0.52, total cholesterol r = -0.51, leptin r = 0.60
p-value: p=<0.05 for all stated correlations
Abstract Background Identifying effective strategies to preserve cognitive health is a major concern of contemporary public health research. In this context, blood pressure, blood lipids, and glycemic parameters are well-established contributors to minor and major cardiovascular events, and emerging evidence suggests their association with cognitive impairment. However, the relationship between reductions in these parameters and potential cognitive improvements remains underexplored. Aim To observe whether exercise-induced improvements in blood pressure, blood lipids, and glycemic parameters are related to global cognitive improvement in people with type 2 diabetes mellitus (T2DM). Methods Sixteen participants (64 ± 8 years old) enrolled in a clinical trial (WHO International Clinical Trials Registry Platform, reference U1111-1202-6942) performed the 8-week exercise training program. A comprehensive cognitive test battery, blood pressure, and plasma samples were collected pre- and post-intervention. Results Changes in global cognitive functions were negatively associated with mean blood pressure ( r = −0.74), triglycerides ( r = −0.52), and total cholesterol reductions ( r = −0.51; p < 0.05 for all). In contrast, leptin concentrations showed a positive association ( r = 0.59). No significant associations were observed between changes in cognitive functions and low-density lipoprotein cholesterol (LDL), resistin, adiponectin, fructosamine, glucose, insulin, and Homeostatic Model Assessment (HOMA) indexes. Conclusion A potential link between longitudinal improvements in global cognitive functions and cardiovascular health indicators was observed, though no such relationship was observed with glycemic parameters.
Silveira-Rodrigues et al. (Thu,) conducted a rct in Adults and older adults with type 2 diabetes mellitus, physically inactive ≥ 3 months, no severe neuropathy or retinopathy (n=16). Combined aerobic and resistance exercise training vs. null was evaluated on Change in global cognitive function composite z-score after 8 weeks (Correlations between cognitive function change and risk factor changes: mean blood pressure r = -0.74, triglycerides r = -0.52, total cholesterol r = -0.51, leptin r = 0.60, p=<0.05 for all stated correlations). Combined aerobic and resistance exercise training for 8 weeks improved global cognitive functions correlated with reductions in mean blood pressure (r = -0.74), triglycerides (r = -0.52), total cholesterol (r = -0.51), and increased leptin (r = 0.60) in adults with type 2 diabetes.