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Different methods of adding active ingredients to blank samples do not affect recovery rates, but they do influence variabilities and physical properties of model formulations. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 22, 2026Open Access

Measurement of recoveries and physical properties of model formulations with different methods of adding active ingredients to blank samples

Key Points

The central aim is to evaluate how different methods of adding active ingredients to blank samples impact recoveries and physical properties.
Prepared model formulations using various addition methods for active ingredients.
Measured recoveries and physical properties of each formulation.
Applied direct addition or solution addition followed by grinding.
No differences in recoveries were observed across the addition methods.
Variabilities in physical properties differed significantly based on the method of addition.
Optimal addition was ≥50 mg/batch for direct addition or ≥2 mL/batch for solution addition (with solvent removal).

Abstract

A sample preparation method for measuring recovery is to add the active ingredient of a solution or standard to a solid blank sample. Model formulations were prepared by various addition methods, and recoveries and physical properties were measured. The results showed no differences in the recoveries depending on the addition method, but the variabilities and physical properties differed. It was suggested that the most appropriate method was to add ≥50 mg/batch when the standard was added directly, or ≥2 mL/batch when the solution was added (solvent was removed), followed by grinding.

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