What does this research mean for the field?

Degree of compaction on day 4, iDAScore, and cell numbers on day 3 are independent predictors of transferable blastocyst formation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to develop a model that predicts the potential of embryos to develop into transferable blastocysts.

February 24, 2026Open Access

Practical prediction model for day 4 embryonic development potential: integration of morphology and AI scoring

YGYasong Geng FDFangfang DaiHebei Medical University HDHaoyang Dai

Key Points

The aim is to develop a model that predicts the potential of embryos to develop into transferable blastocysts.
Utilized day 3 cell numbers and degree of compaction on day 4 as predictors.
Integrated iDAScore to assess embryo morphology.
Developed a nomogram as a tool for predicting outcomes.
Identified compaction degree and iDAScore as strong, independent predictors.
Demonstrated strong model performance for predicting transferable blastocyst formation.

Abstract

Degree of compaction on day 4, iDAScore, and cell numbers on day 3 are independent predictors of transferable blastocyst formation. The proposed nomogram provides an effective tool for predicting embryonic development potential, with strong performance across multiple outcomes.

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