What question did this study set out to answer?

To assess the outcomes of oral food challenges (OFCs) in children diagnosed with IgE-mediated food allergies.

March 4, 2026

Outcomes of oral food challenge in children with IgE-mediated food allergy.

Key Points

To assess the outcomes of oral food challenges (OFCs) in children diagnosed with IgE-mediated food allergies.
Conducted oral food challenges to evaluate clinical reactivity to common allergens.
Analyzed data on sensitization markers like sIgE and SPT values.
Identified independent associations with OFC positivity.
OFC positivity was found in 12.3% of the challenges.
Severe allergic reactions included anaphylaxis, even with low sensitization marker values.
Older age and a history of urticaria or anaphylaxis were linked to higher OFC positivity.

Abstract

OFC positivity was 12.3%, and was predominantly triggered by milk, tree nuts, and eggs. Severe reactions, including anaphylaxis, occurred despite low sIgE and SPT values, confirming the limited utility of sensitization markers in predicting clinical reactivity. Older age, longer follow-up, history of urticaria or anaphylaxis, and challenges with milk, sesame, or hazelnut were independently associated with positive OFCs. These results underscore the critical role of risk-stratified, closely monitored OFCs in ensuring diagnostic accuracy and guiding safe, personalized management in pediatric IgE-mediated food allergy.

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