Impact of neutron sieve therapy for deep site in boron neutron capture therapy using Monte Carlo calculation

Abstract Recent Boron neutron capture therapy (BNCT) has shifted to accelerator-based systems. One of them is a compact neutron generator developed using silicon carbide (SiC) semiconductors by Fukushima SiC Applied Technology Co. However, neutron penetration remains a critical challenge for treating deep-seated tumors. This study investigated the potential of neutron sieve therapy, originally developed to enhance the depth dose distribution in X-ray therapy, to improve BNCT dose distribution via Monte Carlo simulations based on the Fukushima SiC BNCT system. Dose distribution changes were investigated using polyethylene and 6LiF-plastic in block and sieve shapes. The results show that the maximum thermal neutron fluence depth was shallower (deeper) with polyethylene (6LiF-plastic) filters. The sieve filter moderately altered the dose distribution compared to the block filter due to density differences. The maximum dose point shifted 8 mm deeper using a sieve filter composed of 6LiF-plastic and polyethylene, with a 5.5% increase at 20 mm depth in neutron fluence at the same skin dose.