Postoperative radiation therapy in left breast cancer patients causes sustained subclinical myocardial changes detectable by biomarkers, GLS, and PET/CT up to one year.
Does postoperative radiation therapy induce subclinical cardiac changes detectable by multimodal imaging and biomarkers in patients with left breast cancer?
Postoperative radiation therapy for left breast cancer induces sustained subclinical myocardial changes detectable by biomarkers, echocardiography, and PET/CT up to one year post-treatment.
Absolute Event Rate: 0% vs 0%
Background/Objectives: This prospective study aimed to investigate asymptomatic microscopic changes in the myocardium following postoperative radiation therapy (RT) in patients with left breast cancer using multi-medical assessment techniques. Methods: This study included 16 left-sided breast cancer patients who received postoperative RT between January 2021 and December 2022 at our institution. Cardiac examinations were performed before RT and at 1, 12, 24, and 48 weeks after RT. We conducted comparative analyses between pre-RT and various post-RT time points, exploring correlations between changes in hematologic biomarkers, global longitudinal strain (GLS), and myocardial metabolism. Results: Inflammatory biomarkers such as the neutrophil–lymphocyte, platelet–lymphocyte, and lymphocyte–monocyte ratios changed between the pre- and post-RT periods but returned to normal levels after several months. However, troponin T and soluble suppression of tumorigenicity 2 showed sustained changes during the 1-year follow-up period. Among echocardiographic parameters, GLSLAX showed a significant difference between pre-RT and post-RT assessments. Additionally, irradiated and non-irradiated myocardial metabolic ratios on 18F-fluorodeoxyglucose positron emission tomography/computed tomography differed between pre-RT and post-RT and remained altered up to one year after treatment. Conclusions: These findings suggest that subclinical myocardial changes may persist following RT, although the clinical significance of subclinical myocardial changes remains uncertain and warrants further investigation.
Won et al. (Tue,) reported a other. Postoperative radiation therapy in left breast cancer patients causes sustained subclinical myocardial changes detectable by biomarkers, GLS, and PET/CT up to one year.