What question did this study set out to answer?

The study investigates the effects of syringin on cardiac hypertrophy caused by pressure overload, focusing on autophagy mechanisms.

March 8, 2026Open Access

Expression of Concern Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy

Key Result

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Key Points

The study investigates the effects of syringin on cardiac hypertrophy caused by pressure overload, focusing on autophagy mechanisms.
Analysis of cardiac hypertrophy using pressure overload models
RT-qPCR to measure gene expression levels
Comparison of protein blots for p-AMPKα and ATG7
Concerns raised regarding data integrity and similarity between figures
No response from authors regarding the discrepancies reported
Investigation ongoing by the Editorial Office

Limitations

Data integrity concerns due to duplication of blot images in figures.
No author response to explain anomalies in data presentation.
Editorial expression of concern issued pending further investigation.

Abstract

Following the publication of the above paper, a concerned reader has drawn to the Editor's attention that the data shown for the p-AMPKα blots with the RT-qPCR analysis in Fig. 2B on p. 203 are strikingly similar to the ATG7 blots shown in Fig. 4A on p. 205. The authors were contacted by the Editorial Office to offer an explanation for this apparent anomaly in the presentation of the data in this paper, although up to this time, no response from the authors has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. International Journal of Molecular Medicine 39: 199-207, 2017; DOI: 10.3892/ijmm.2016.2824.

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