Protective Effects of Pentoxifylline on Peripheral Microcirculatory Dysfunction and Renal Cortical Oxygen Deficiency in a Rat Model of LPS ‐Induced Sepsis

Key Points

• This research aims to evaluate the protective effects of pentoxifylline on microcirculatory dysfunction and renal oxygen levels in a sepsis model.
• Utilized a rat model induced with LPS to simulate sepsis.
• Administered pentoxifylline and monitored its effects on renal oxygenation and microcirculation.
• Assessed tissue damage and inflammatory cell infiltration in renal sections.
• Pentoxifylline improved renal oxygenation levels in the sepsis model.
• There was a notable enhancement in peripheral muscle microcirculation post-treatment.
• Reduced evidence of renal damage and inflammatory cell infiltration was observed.

Abstract