Influence of frailty syndrome on disease outcomes in systemic lupus erythematosus: a systematic review and narrative synthesis

Key Points

• The aim is to examine the effect of frailty syndrome on adverse disease outcomes in patients with systemic lupus erythematosus.
• Conducted a systematic review of existing literature
• Evaluated definitions of frailty in relation to SLE
• Analysis included longitudinal studies for better understanding
• Patients with frailty show a higher risk of adverse outcomes in SLE
• Standardized definitions of frailty are lacking
• Need for targeted interventions to manage risk effectively