What type of study is this?

This is a Validation Study study.

What question did this study set out to answer?

To develop a machine learning algorithm for predicting incident opioid use disorder (OUD) among OneFlorida+ patients.

March 14, 2026Open Access

Developing and Validating a Machine Learning Algorithm to Predict the Risk of Incident Opioid Use Disorder Among OneFlorida+ Patients: Prognostic Modeling Study

JFJabed Al FaysalUniversity of Florida WLWeihsuan Lo-CiganicUniversity of Pittsburgh WGWalid F. GelladUniversity of Pittsburgh

Key Points

To develop a machine learning algorithm for predicting incident opioid use disorder (OUD) among OneFlorida+ patients.
Developed a machine learning algorithm using OneFlorida+ EHR data.
Performed external validation of the algorithm with UPMC data.
Assessed algorithm's performance for risk prediction and stratification.
The algorithm showed strong performance in external validation.
It has potential for effective risk prediction of incident OUD.
Findings could support early intervention strategies across health systems.

Abstract

An ML algorithm predicting incident OUD derived from OneFlorida+ EHR data performed well in external validation with data using UPMC. The algorithm might be valuable for incident OUD risk prediction and stratification across health systems, with potential to inform early intervention.

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