Anticipating and overcoming resistance in blastic plasmacytoid dendritic cell neoplasm: new insights from pivekimab sunirine

Key Points

• This work aims to explore resistance in blastic plasmacytoid dendritic cell neoplasm and examine strategies to overcome it.
• Investigated mechanisms of resistance in blastic plasmacytoid dendritic cell neoplasm
• Analyzed the effects of pivekimab sunirine on neoplasm
• Employed both in vitro and in vivo models for analysis
• Identified specific resistance mechanisms in dendritic cells
• Showed potential efficacy of pivekimab sunirine in overcoming resistance
• Demonstrated improved outcomes in models treated with pivekimab sunirine

Abstract