Introduction: The combination of positive end-expiratory pressure (PEEP) and heliox is an alternative to optimize aerosol. Background: Assess the influence of nebulization with bronchodilators adduced by heliox associated with PEEP in lung function and deposition radioaerosol in stable asthmatics during. Methods: Randomized controlled trial double-blind study involving 32 patients (mean age 47±10 years) divided into four groups: G1: Heliox PEEP + G2:Oxygen + PEEP, G3:Heliox, and G4:Oxygen-submitted to inhalation lung scintigraphy with bronchodilators. Spirometry and cardiopulmonary parameters were evaluated before and after intervention. The deposition index (DPI) was obtained by the ratio of counts in each region of interest (ROI) by the total counts of the right lung and inspiratory capacity (IC) regional obtained by multiplying the total by IC. Statistical analysis used Fisher's tests, Kruskal-Wallis, Mann-Whitney, Wilcoxon and ANOVA considering p <0.05. Results: Results Post-intervention, the G1 had increased values of predicted FEV1 (p=0.029) and IC (p=0.004). In reviewing the DPI the groups, there was a higher DPI in the middle third (44±3%, p = 0.001) and intermediate region (40±2%, p <0.01). In assessing the DPI between groups, no difference. The IC was higher in regional G1 and G2 (p <0.05). Conclusion: The nebulized bronchodilators and heliox combined with PEEP improved lung function. The deposition of drugs was higher in the middle third and intermediate portion of the lungs in all groups. In evaluating the IC regional groups associated with PEEP showed higher values independent of the gas used.
Alcoforado et al. (Thu,) studied this question.
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