S E Ar-based reductive arylation of indoles with ketones: skeletal metamorphosis of ketones into aryl architectures

Key Points

• To explore the arylation of indoles using ketones through a novel reductive S E Ar method.
• Developed a new method for arylation of indoles with ketones.
• Utilized reductive electrophilic aromatic substitution techniques.
• Investigated reaction conditions for optimal product yield.
• Achieved successful transformation of ketones into aryl architectures.
• Demonstrated the feasibility of this novel transformation for the first time.