Nano-Based Drug Delivery System for Psoriasis Management: A Comprehensive Review

Psoriasis is an autoimmune and inflammatory conditions and characterized by red, inflammatory plaques and macules that develop due to poor differentiation and increased proliferation of keratin-produced by epidermal cells. Pathophysiology, including as immune cells, genetic predisposition, antimicrobial peptides, and non-coding RNAs. The traditional prescription drugs are not enough to control the condition because they have many drawbacks. They are link to large dosage of drugs and the potential for toxicity and the adverse effects, which can result in long- term poor patient compliance. Nanotechnology-based approaches aiming at a greater therapeutic effect in order to get beyond the aforementioned restrictions and allow tailored pharmaceuticals treatments for psoriasis and reduced toxicity in psoriasis topical treatment. This comprehensive review included the type, onset of disease and pathophysiology of psoriasis, conventional treatment, the need for nano based drug delivery systems for the treatment of psoriasis and also described the nanobased drug delivery approaches such as lipid based nanocarriers: - nanoemulsion, liposomes, ethosomes, transferosomes, cerosomes, NLC, SLN and polymer based nannocarriers such as: - hydrogels, nanosphere nanocapsules, dendrimers and also metallic nanocarriers: - gold and silver nanoparticles. The review was prepared through literature search using the databases ScienceDirect, PubMed, and Google Scholar. The review article offered information on the utilization of nano carriers while talking about the drawbacks of traditional psoriasis treatment. Throughout the skin's penetration and permeation process, the biodegradable nanoformulations usually result in targeted drug administrations. Additionally, it controls drug release, avoids toxicity, and protects labile compounds from degradation. Keywords: Psoriasis, Nanotechnology, Traditional medicines, Nanocarriers