Abstract Background: The threat of a nuclear exchange represents an apex hazard to global ecological stability and human continuity. Historically, disaster management paradigms have been paralyzed by fatalism regarding nuclear survivability. Objective: This paper synthesizes contemporary empirical modeling, materials science, and pharmacological advancements to establish a multidimensional framework for nuclear conflict survivability. Methods: A comprehensive systematic literature review was conducted, evaluating data across civil defense engineering, acute radiation syndrome (ARS) countermeasures, and Abrupt Sunlight Reduction Scenarios (ASRS). Results: Survival probability scales linearly with pre-event infrastructural hardening and decentralized civilian preparedness. Expedient technologies, including the Kearny Air Pump (KAP) and Kearny Fallout Meter (KFM), remain critical for subterranean habitability. Pharmacologically, the administration of cytokines (e.g., filgrastim) and novel agents including IEPA and IPW-5371 demonstrate significant efficacy in mitigating hematopoietic and delayed multi-organ radiation effects. Ecologically, macroalgae (Gracilaria tikvahiae) and single-cell proteins (SCP) offer highly scalable, sunlight-independent nutritional resilience during nuclear winter. Institutional coordination integrating regulatory bodies and disaster management agencies is vital for effective public protective actions. Conclusion: Survivability is structurally manageable through the rigorous, preemptive integration of physical shielding, medical countermeasures, chemotrophic agricultural shifts, and psychosocial resilience frameworks.
Samuel Darwisman (Sun,) studied this question.