Obesity was positively but negligibly associated with a higher V̇E/V̇CO2 slope during exercise compared to adults without obesity (median 25.0 vs 24.7; p<0.001).
Cross-Sectional (n=3,534)
Yes
Is obesity associated with a higher V̇E/V̇CO2 slope during exercise in apparently healthy adults?
Obesity is positively but negligibly associated with a higher V̇E/V̇CO2 slope during exercise in apparently healthy adults.
Effect estimate: ρ 0.079
Absolute Event Rate: 25% vs 24.7%
p-value: p=<0.001
ABSTRACT A high minute ventilation/rate of carbon dioxide production (V̇ E /V̇CO 2 ) slope during exercise is prognostic for cardiovascular mortality among clinical populations. Obesity represents a major modifiable risk factor for cardiovascular disease. However, it is unclear whether body mass index (BMI) is associated with V̇ E /V̇CO 2 slope among apparently healthy adults. Therefore, we used the Fitness Registry and the Importance of Exercise National Database (FRIEND) to determine whether BMI is positively associated with V̇ E /V̇CO 2 slope in the context of apparently healthy adults. All participants completed a cardiopulmonary exercise test on a cycle ergometer. Linear regressions adjusted for age, sex, and race/ethnicity were used to compare the V̇ E /V̇CO 2 slope between adults with and without obesity (BMI </≥ 30 kg/m 2 ). Partial correlation adjusted for age, sex, race/ethnicity, and cardiorespiratory fitness was used to determine the relation between the V̇ E /V̇CO 2 slope and BMI. All data are presented as median IQR. We set α a priori to < 0.05. The sample ( n = 3534) characteristics were as follows: (1) age = 40 (17) years; (2) 20% female; (3) cardiorespiratory fitness = 27.810.8 mL O 2 ●kg −1 ●min −1 and (4) BMI = 26.15.0 kg/m 2 . V̇ E /V̇CO 2 slope was higher in adults with obesity 25.03.5 compared to those without obesity 24.73.6 with a negligible effect size ( R 2 = 0.132, adjusted R 2 = 0.131, F 4,3529 = 134, p < 0.001). V̇ E /V̇CO 2 slope was weakly associated with BMI across the cohort (ρ = 0.079, p < 0.001). Obesity was positively, but negligibly, associated with a higher V̇ E /V̇CO 2 slope in the FRIEND Registry.
Bissen et al. (Sun,) conduziram um estudo transversal em adultos aparentemente saudáveis (n=3.534). A obesidade (IMC ≥ 30 kg/m2) vs. Sem obesidade (IMC < 30 kg/m2) foi avaliada na inclinação V̇E/V̇CO2 (ρ 0,079, p=<0,001). A obesidade foi positivamente, mas negligivelmente, associada a uma maior inclinação V̇E/V̇CO2 durante o exercício em comparação com adultos sem obesidade (mediana 25,0 vs 24,7; p<0,001).
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