What question did this study set out to answer?

This research aims to compare the overnight corneal swelling response between adapted and unadapted contact lens wearers.

March 21, 2026

Overnight Corneal Swelling Response in Adapted and Unadapted Extended Wear Patients

Key Points

This research aims to compare the overnight corneal swelling response between adapted and unadapted contact lens wearers.
Compared two groups: six unadapted and six adapted subjects wearing hydrogel lenses.
Measured baseline corneal thickness in the evening and after 7.5 hours of sleep.
Examined corneal thickness changes under open-eye conditions the next morning.
Unadapted subjects exhibited more overnight corneal swelling compared to adapted subjects.
Swelling was measured at each time interval for 3 hours after waking.
The rate of corneal deswelling was consistent across both groups.

Abstract

ABSTRACT This investigation compared the overnight swelling response in adapted and unadapted subjects who were wearing a 0.035 mm, low water content hydrogel contact lens. Six subjects who had not worn contact lenses previously (unadapted) and six subjects who had worn extended wear hydrogel lenses for 1.5 years participated in the study. Baseline corneal thickness measurements were taken in the evening and after 7.5 h of sleeping with the lenses on overnight. The unadapted subjects showed more overnight swelling and at each time interval for 3 h the next morning under open‐eye conditions. The rate of deswelling was the same for each group.

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