Long-term Outcomes after Endoscopic Submucosal Dissection for T1 Colorectal Cancer: A Multicenter Prospective Study

Key Points

• To evaluate long-term outcomes of endoscopic submucosal dissection (ESD) for T1 colorectal cancer (CRC).
• Conducted a multicenter prospective study
• Assessed patients with low-risk and high-risk T1 CRC
• Monitored for recurrence and disease-specific mortality
• No recurrence or disease-specific mortality in low-risk T1 CRC patients
• High-risk T1 CRC may require additional surgery to prevent local recurrence
• Uncertainty remains about the impact of surgery on distant metastasis and disease-specific survival (DSS)