Objective: To assess the global, regional, and national burden and trends of endometriosis-related infertility in women of reproductive age. Methods: Data were extracted from the Global Burden of Disease Study 2021. We analyzed the number of cases, all-age and age-standardized prevalence rates, and relative changes globally, regionally, and nationally, stratified by age and Socio-demographic Index (SDI) quintiles. An age-period-cohort model was used to estimate net drifts, local drifts, and period/cohort-specific relative risks from 1990 to 2021. Results: From 1990 to 2021, prevalent cases increased by 9.1% (1.09 million to 1.19 million). Global all-age prevalence rate decreased by 29.07% (42.52 to 30.16 per 100,000), and age-standardized prevalence rate decreased by 28.38% (41.89 to 30.00 per 100,000). The annual net drift was -1.03%, ranging from -1.58% in low SDI regions to -0.68% in high SDI regions. Age distribution transitions were observed in high, high-middle, and middle SDI regions. Relative risks declined over time and across younger cohorts, except in high SDI regions after 2000. Conclusions: Endometriosis-related infertility reflects endometriosis prevention and treatment trends. The increasing number of cases alongside declining prevalence rates highlights the need for targeted interventions to reduce the global burden.
Yan et al. (Wed,) studied this question.
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