High right ventricular pacing burden (≥30%) increased LVEF deterioration compared to low burden (13% vs 2%, p<0.05), with early LV-GLS decline strongly predicting this outcome (HR 7.210).
Cohort (n=105)
Double-blind
No
Does high right ventricular pacing burden increase LVEF deterioration and LV-GLS decline in patients with dual-chamber pacemakers?
Early decline in left ventricular global longitudinal strain serves as a sensitive predictor for subsequent pacing-induced cardiomyopathy in patients with high right ventricular pacing burden.
Absolute Event Rate: 13% vs 2%
p-value: p=<0.05
Background and Aims: Permanent pacemaker (PM) implantation is an established treatment for symptomatic bradycardia. However, chronic right ventricular pacing (RVP) is associated with increased morbidity and mortality due to electrical and mechanical dyssynchrony, leading to pacing-induced cardiomyopathy (PICM). Prognostic markers for identifying patients at high risk of PICM remain scarce. This study compares patients with low (50%, excluding alternative causes). Of the 105 patients, 58 (55%) were classified into the low RVP group (10% from baseline serves as an early and sensitive marker for subsequent LVEF deterioration and is associated with adverse outcomes. Early LV-GLS monitoring may help identify patients at higher risk for progressive ventricular dysfunction.
Plappert et al. (Thu,) conducted a cohort in Symptomatic bradycardia (n=105). High right ventricular pacing (RVP) burden (≥30%) vs. Low RVP burden (<30%) was evaluated on LVEF deterioration (≥10% decrease from baseline >50%) (p=<0.05). High right ventricular pacing burden (≥30%) increased LVEF deterioration compared to low burden (13% vs 2%, p<0.05), with early LV-GLS decline strongly predicting this outcome (HR 7.210).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: