Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. The present study aimed to evaluate the protective effects of a probiotic against experimentally induced gastric ulcers in rats. Male Wistar rats were allocated into five groups (n = 6 per group): Control, Model (indomethacin-induced ulcers, IND), Positive control (IND + famotidine), IND + Laktera Nature (LN) probiotic (800 mg/kg), and IND + LN probiotic (1600 mg/kg). The study duration was 14 days. On day 15, rats in groups 2–5 received 1 mL of indomethacin (40 mg/kg) orally. All rats were euthanized four hours later via cervical dislocation under diethyl ether anesthesia. LN probiotics have demonstrated dose-dependent protection against indomethacin-induced gastric ulcers, as assessed by both macroscopic and microscopic evaluation. Therefore, LN probiotics may represent a valuable adjunctive strategy in the management of gastric ulcers.
Georgiev et al. (Tue,) studied this question.