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This is a Systematic Review study.

March 22, 2026Open Access

Modifiable Risk Factors for Alzheimer's Disease in Latin America: A Systematic Review of Epidemiological Evidence (2000-2024)

Key Points

To systematically review modifiable risk factors for Alzheimer's disease in Latin American populations.
Analyzed 63 studies from 2000 to 2024
Focused on 12 risk factors identified by the Lancet Commission
Calculated population-attributable fraction estimates
Estimated population-attributable fraction of 35-48% for modifiable risk factors
Low educational attainment identified as a high-priority target (OR 1.8-3.2)
Hypertension also prioritized (OR 1.6-2.4)

Abstract

Systematic review of modifiable risk factors for Alzheimer's disease in Latin American populations (2000-2024). Analyzes 63 studies examining 12 Lancet Commission risk factors. Combined population-attributable fraction estimates: 35-48%. Low educational attainment (OR 1.8-3.2) and hypertension (OR 1.6-2.4) are the highest-priority targets. Linked dataset: https://doi.org/10.7910/DVN/UVHABW (CC0 1.0)

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Authors

Juan Moisés de la Serna

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Institutions

Universidad Internacional De La Rioja

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Modifiable Risk Factors for Alzheimer's Disease in Latin America: A Systematic Review of Epidemiological Evidence (2000-2024)

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Abstract

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Authors

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