Introduction: Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm occurring less frequently in adults than in children. Although various organs can be affected, resulting in a heterogenous clinical presentation, liver involvement is uncommon, particularly in adults. Herein, we present a case of LCH with liver involvement in an adult patient. Case Report: A 40-year-old man presented with painless jaundice and abnormal liver function tests. Diagnostic work-up revealed hepatosplenomegaly, and excluded common causes of liver dysfunction. Liver biopsy revealed microscopic findings typical of the disease and positive immunohistochemical markers. Hepatoprotective therapy resulted in improvement in liver function and withdrawal of symptoms. Conclusions: Isolated LCH-related liver injury is rare. The differential diagnosis with other liver pathology may pose a challenge for clinicians and radiologists.
Trpchevska et al. (2026) studied this question.