What question did this study set out to answer?

This research aims to enhance diabetes diagnosis by employing explainable AI techniques for machine learning models.

March 25, 2026

Explainable Artificial Intelligence for Diabetes Diagnosis

MLMohamed Lamri ASAbdelhakim SahourAbbès Laghrour University of Khenchela FBFarouk BoumehrezLaboratoire Traitement et Communication de l’Information

Key Points

This research aims to enhance diabetes diagnosis by employing explainable AI techniques for machine learning models.
Explored SHAP and LIME for generating explanations of machine learning predictions
Collected data from Kaggle and used diverse machine learning algorithms
Applied multiple models, including CatBoost, XGBoost, SVM, RF, AdaBoost, LR, LightGBM, and DT
SHAP and LIME effectively identified patient symptom patterns
Demonstrated improved accuracy and interpretability in diabetes prediction
Achieved high performance metrics such as accuracy, recall, AUC-ROC, and F1 score on the test set

Abstract

Whether young, old, type 1, type 2, gestational, newly diagnosed, long-time sufferer, caretaker or loved one, millions of people are afflicted and affected by diabetes. The World Health Organization (WHO) predicts that by 2030, diabetes will be the 7th leading cause of death in the world, and estimated more than 422 million adults of the population worldwide are living with diabetes, with millions of people with prediabetes. Machine learning models have shown promising results in the correct identification of the presence of diabetes, which is essential for providing efficient treatment; however, their decision-making process is often considered a “black box” that lacks transparency and interpretability. In this project, we explored the use of Shapley Additive exPlanations (SHAP) and Local Interpretable Model-agnostic Explanations (LIME), two popular explainable AI techniques, to generate local and global explanations for machine learning models. All the datasets used for the study were gathered from Kaggle and split into training and test sets using different kinds of machine learning algorithms, which would boost the success rate of therapy. Along with Categorical Boosting (CatBoost), Extreme Gradient Boosting (XGBoost), Support Vector Machine (SVM), Random Forest (RF), Adaptive Boosting (AdaBoost), Logistic Regression (LR), Light Gradient Boosting Machine (LightGBM), and Decision Trees (DT) are well-known models for predicting diabetes and managing therapy. Explainable AI techniques were then applied to generate explanations of the model’s predictions on the test sets. Our results demonstrated that SHAP and LIME can effectively identify patterns in the symptoms of patients and suggest a potential diagnosis or recommend further courses of action. In addition, this study also presents a comparative analysis of these algorithms based on various performance metrics, such as accuracy, recall, AUC-ROC, and F1 score, achieving the highest values on the test set, indicating the potential of combining machine learning and explainable AI for improving diabetes diagnosis and treatment.

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