Apolipoprotein M (ApoM) is a carrier of sphingosine-1-phosphate (S1P) and ApoM-S1P exerts potent physiological effects mainly through S1P1 receptor. We previously reported protective effects of ApoM in a multiple organ failure in sepsis mouse model, IgA nephropathy mouse model, and diabetic nephropathy mouse model and its potential as a therapeutic target. Here, we investigated the roles of ApoM in cisplatin-induced nephropathy using a mouse model and potential novel downstream mechanisms modulated by ApoM.
Nakano et al. (Wed,) studied this question.