What question did this study set out to answer?

This article aims to summarize Jerome Karle's contributions to crystallography and his collaborative work with his wife.

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March 28, 2026

Jerome Karle (1918–2013), Pioneer Crystallographer and 1985 Nobel Chemistry Laureate, Dies at Age 94

Key Points

This article aims to summarize Jerome Karle's contributions to crystallography and his collaborative work with his wife.
Provided an overview of Karle’s life and achievements
Discussed his key contributions to crystallography
Examined the implications of his wife’s omission from the Nobel Prize award
Karle was awarded the Nobel Prize in Chemistry in 1985 for his work in crystallography.
He worked closely with his wife, who was not acknowledged in the Nobel Prize.
Karle passed away at the age of 94 due to liver cancer.

Abstract

Jerome Karle (1918–2013), winner of the 1985 Nobel Prize in Chemistry and oldest living Nobel chemistry laureate, died of liver cancer on June 6, 2013 at the age of 94 at the Leewood Healthcare Center in Annandale, Virginia. He shared the Prize with the mathematician Herbert A. Hauptman (1917–2011). This article summarizes Karle’s life, career, and research, especially his Nobel-winning work. The failure to include his wife, Isabella Helen Karle (née Lugoski) (b. 1921), who collaborated fully in the award-winning work, in the Nobel Prize even though as many as three recipients may be included, is also discussed.

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