La Profilée: Structural Measurement Framework - How to Measure IR in Practice: Proxy Variables, Early Warning, and Structural Diagnosis Across Domains

La Profilée (LP) specifies a universal necessary condition for structural persistence: the Integration Ratio IR = R / (F · I) must remain at or below 1. Prior publications have demonstrated that this condition applies across organisational and biological failure modes, and that the Tᵥisible interval — the delay between structural overload onset and visible pathological manifestation — is empirically documented in both domains. This paper addresses the next question: how is IR measured in practice? The direct measurement of IR requires operationalisation of four variables (F, M, R, I) across domains. This paper proposes a domain-general proxy framework based on the following principle: LP variables are not directly observable, but their structural effects are. Every domain has observable indicators of Frame stability, Module activity, Transformation pressure, and Integration capacity. These indicators do not measure LP variables — they proxy the structural conditions those variables represent. The paper develops proxy frameworks for three domains: Biological systems: F-proxies (transcription factor stability, differentiation markers, genomic integrity indices) ; R-proxies (inflammatory markers, oxidative stress indices, metabolic stress indicators) ; I-proxies (ATP production rate, repair enzyme activity, proteostasis capacity). Organisational systems: F-proxies (identity coherence indicators, governance stability metrics, cultural consistency measures) ; R-proxies (transformation pressure indices from market, technology, regulatory dimensions) ; I-proxies (decision velocity, resource liquidity, strategic integration capacity). Person-level systems: F-proxies (identity clarity, values consistency, self-continuity perception) ; R-proxies (role demand load, existential challenge intensity, environmental disruption) ; I-proxies (psychological energy, cognitive flexibility, emotional regulation capacity). In all three domains, the structural diagnosis IR > 1 is in principle computable from observable proxies before the visible pathological manifestation — establishing LP as a prospective early-warning framework, not merely a retrospective analytical tool.