What question did this study set out to answer?

This research aims to develop a cobalt-catalyzed three-component coupling strategy involving aldehydes, allenes, and aryl halides.

March 29, 2026Open Access

Cobalt-Catalyzed Three-Component Reductive Coupling of Aldehydes, Allenes, and Aryl Halides

Key Points

This research aims to develop a cobalt-catalyzed three-component coupling strategy involving aldehydes, allenes, and aryl halides.
Utilized cobalt as a catalyst for reductive coupling
Involved three components: aldehydes, allenes, and aryl halides
Showed regio- and stereoselectivity in product formation
Explored functional group tolerance through multiple examples
Successfully generated stereodefined trisubstituted alkenylsilanes
Demonstrated broad functional group tolerance with 40 examples
Provided a mechanism involving oxidative addition through halide abstraction

Abstract

A Co-catalyzed reductive three-component coupling of aldehydes, allenes, and aryl halides is described. The reaction is both regio- and stereoselective and produces stereodefined trisubstituted alkenylsilanes that can be converted into trisubstituted alkenes. Broad functional group tolerance was demonstrated through 40 examples, with an oxidative addition mechanism proceeding through halide abstraction.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Joshua D. Sieber

Magdalene D. Togoh

Sara Azad

Journals

Organic Letters

Actions

Institutions

Virginia Commonwealth University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Cobalt-Catalyzed Three-Component Reductive Coupling of Aldehydes, Allenes, and Aryl Halides

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider