Cosmeceuticals, bridging cosmetics and pharmaceuticals, have advanced through nanotechnology And Artificial Intelligence (AI) to overcome the skin penetration and bioavailability challenges faced by conventional formulations. This review discusses technological progress, clinical applications, and regulatory and market perspectives, aiming to highlight how these approaches enhance efficacy, safety, and personalization in cosmeceutical development. Recent studies were reviewed on nanocarrier systems, including liposomes, solid lipid nanoparticles, nanoemulsions, micelles, and hydrogel-based carriers, and AI-driven tools for predictive modeling, formulation optimization, and personalized skincare. Complementary technologies such as 3D printing and microneedles were also examined. Nanocarriers enhance stability, penetration, and controlled release of active ingredients, addressing limitations of conventional formulations. AI enables predictive analysis and consumer-specific design by integrating dermatological data and machine learning. The combined use of nanotechnology and AI supports customized, high-performance cosmeceuticals. Applications include antiaging, anti-wrinkle, acne, and hyperpigmentation therapies, with evidence of improved outcomes compared to traditional products. Nanotechnology and AI are reshaping cosmeceutical development, offering innovative delivery, personalization, and higher consumer confidence. Their integration signals a shift toward nextgeneration cosmeceuticals, but continued innovation, regulatory adaptation, and market translation are required to achieve widespread clinical and commercial success.
Kee et al. (Thu,) studied this question.