Abstract Objectives Peri‐procedural rectal indomethacin was shown to decrease the incidence of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in adults undergoing ERCP. This practice was generalized to pediatric populations, despite an absence of data on safety or efficacy. This study evaluated the safety and efficacy of rectal indomethacin in pediatric patients undergoing ERCP. Methods We conducted a retrospective, cohort study of pediatric patients undergoing ERCP (single‐endoscopist) at two tertiary academic hospitals from November 2009 to August 2024. Safety outcomes included bleeding and acute kidney injury (AKI). The efficacy outcome was incidence of PEP with and without indomethacin at 100 mg > 30 kg and 50 mg 30 kg and 50 mg < 30 kg.
Camacho et al. (Mon,) studied this question.
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