Poorly differentiated thyroid carcinoma (PDTC) is a rare and highly malignant tumor. To date, there have been very few case reports on PTCD, so its treatment methods remain controversial and require more experience. The island-like, solid-like or trabecular-like structures are manifestations of histology. Most PDTCs show positive reactions for thyroid globulin and thyroid transcription factor 1 (TTF-1) in immunohistochemical tests, and some of them also show positive reactions for p53. A 55-year-old male patient presented with a left neck mass without any obvious cause. He was diagnosed with advanced PDTC. We adopted a treatment plan combining local radiotherapy and intravenous chemotherapy. The PET/CT scan showed no increased metabolic activity throughout the body. This patient has achieved complete remission. The overall survival period is currently around one year. Additionally, we provide a comprehensive review of the disease, emphasizing incidence and definition, clinical symptoms and prognosis, molecular characteristics and treatment of PDTC, which may offer valuable insights for clinical practitioners.
Zeng et al. (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: