Patient-specific fluid-structure interaction models accurately simulated aortic valve dynamics, demonstrating 5-8% average error for mean transvalvular flow and 7-10% error for aortic valve area.
Does a patient-specific Fluid-Structure Interaction (FSI) model accurately simulate aortic valve dynamics compared to in vitro experiments?
Patient-specific Fluid-Structure Interaction modeling accurately replicates in vitro aortic valve dynamics, demonstrating its potential as a non-invasive tool to assess aortic stenosis severity.
Absolute Event Rate: 0% vs 0%
Aortic stenosis (AS) severity is typically assessed by measuring pressure drop across the aortic valve in rest. However, this flow-dependent metric is influenced by patients' cardiac function, complicating clinical decision-making on valve replacement. Moreover, assessment during rest does not reflect valvular dynamics under higher flow rates (e.g., during exercise), and may underestimate severity in moderate AS patients. Patient-specific Fluid-Structure Interaction (FSI) modelling offers a promising, non-invasive method to simulate valve dynamics under varying conditions, independent of pressure exerted by the left ventricle. Therefore, this study aimed to experimentally verify an aortic stenosis FSI model using a patient-specific aortic valve geometry, including calcifications, across flow conditions ranging from rest to exercise. To achieve this goal, in vitro experiments were conducted using a mock-loop circulatory system with patient-specific silicone rubber valve models, both calcified and non-calcified. These experiments were replicated in FSI simulations. Overall, good agreement was observed between simulated and experimental results for the non-calcified valve in terms of mean transvalvular flow (5% error on average) and aortic valve area (AVA) (10% error on average). Discrepancies were more pronounced in the calcified valve due to added complexity and uncertainty introduced by calcifications (8% and 7% error on average for mean transvalvular flow and AVA, respectively). For clinical implementation, two key challenges remain: (1) developing efficient and reliable methods to estimate valve leaflet material properties and pre-stress, and (2) verifying the model against a broader range of in vitro data, followed by validating it against real, clinical data. Despite the remaining challenges, this study demonstrated the feasibility of using FSI models as a complementary, non-invasive tool to assess AS severity and support clinical decision-making on valve replacement.
Verstraeten et al. (Tue,) reported a other. Patient-specific fluid-structure interaction models accurately simulated aortic valve dynamics, demonstrating 5-8% average error for mean transvalvular flow and 7-10% error for aortic valve area.