What question did this study set out to answer?

To examine how aging affects ᵧδ T-cell activity in the progression of metastatic cutaneous melanoma.

April 5, 2026

Abstract 2072: Role of the aging on the ᵧ δ ; T-cells in metastatic cutaneous melanoma progression.

Key Points

To examine how aging affects ᵧδ T-cell activity in the progression of metastatic cutaneous melanoma.
Injected syngeneic melanoma cells into young, aged, and geriatric mice.
Analyzed tissue samples from lungs, liver, and spleen using flow cytometry and histological methods.
Utilized a ᵧδ T cell depletion model to assess the impact on metastasis.
Overexpressed PROS1 in melanoma cells and tracked metastasis and immune cell infiltration.
Middle-aged mice displayed increased ᵧδ T-cell infiltration in metastatic sites compared to young and geriatric mice.
PROS1 overexpression enhanced metastasis in young mice and decreased ᵧδ T-cell infiltration.
Geriatric mice showed lower metastasis, consistent with clinical observations.

Abstract

Abstract Melanoma incidence, metastasis, and mortality are significantly associated with age. Interestingly within the clinic, melanoma incidence is low in young adults, peaks between ages 65-79, and decreases thereafter (79+). This phenomenon has never been studied as pre-clinical studies predominantly focus on young (8-week-old) mouse models. Syngeneic melanoma cells have been injected by IV (lung colonization) and hydrodynamic tail vein injection (liver colonization) into C57/Bl/6 young (8 weeks), aged (12 months) and geriatric (18-24 months) male mice. Spleen, lungs and liver have been collected to analyze metastasis and immune infiltration by flow cytometry. H T-cells in metastatic cutaneous melanoma progression abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 2072.

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