What is the clinical evidence from this study?

Study design: Other. Population: Cancer. Intervention: CP2CT DECC implementation strategies. Primary outcome: Implementation outcomes across administrative, data, program evaluation, and learning collaborative domains.

What question did this study set out to answer?

The central aim is to optimize participant enrollment in clinical trials through a coordinated national effort.

April 5, 2026

Abstract 899: Building a national network coordination center for clinical trials: Early implementation outcomes from the CP2CT DECC.

Key Result

The CP2CT DECC implemented coordinated strategies over three years to establish a sustainable infrastructure for administrative coordination, standardized data collection, and program evaluation.

Key Points

The central aim is to optimize participant enrollment in clinical trials through a coordinated national effort.
Implemented administrative structures with centralized reporting
Standardized data collection using Common Data Elements in a cross-network system
Developed an evaluation infrastructure with a Logic Model and standardized constructs
Created learning supports, including internal websites and speaker series
Facilitated site-level implementation through structured visits
Established infrastructure and centralized reporting platforms
Secured data sharing across institutions improving interoperability
Linked program activities to measurable outcomes via a Logic Model
Developed a centralized hub for resources and expanded educational opportunities

Structured PICO

Population

National network for cancer clinical trials targeting underserved and under-researched populations in the US

Intervention

Implementation of the CP2CT Data, Evaluation, and Coordinating Center (DECC) strategies over three years (administrative structuring, data standardization, evaluation infrastructure, learning supports, and site-level facilitation)

Outcome

Early implementation outcomes across administrative, data, program evaluation, and learning collaborative domains

The CP2CT DECC provides a scalable model for coordinating national research networks to improve clinical trial awareness and accrual in underserved cancer populations.

Abstract

Abstract Background: Despite the decline in overall mortality and incidence of cancer in the US population, the burden of cancer is still high, especially in underserved and under-researched populations. A major contributor to poor cancer outcomes is the absence of dedicated efforts utilizing scientifically rigorous approaches and implementation strategies to optimize participant enrollment and accrual in clinical trials. The Connecting Patient Populations to Clinical Trials (CP2CT) program implements innovative multilevel interventions to enhance clinical trial awareness and optimize referral pathways that facilitate patient enrollment. The CP2CT Data, Evaluation, and Coordinating Center (DECC) supports its data and evaluation activities, and coordinates a learning collaborative towards mitigating the key barriers of cancer burden in all populations. Methods: Using an implementation science-informed approach, the DECC deployed coordinated strategies over three years: (1) administrative structuring through streamlined governance, centralized reporting, and stakeholder integration; (2) data standardization via Common Data Elements (CDEs), a cross-network REDCap system, and a multi-institution Data Transfer Agreement (DTA); (3) evaluation infrastructure through a Network Logic Model, evaluation plan, standardized constructs, and a Process Evaluation Plan with tools; (4) learning supports through an internal website and expanded Speaker Series; and (5) site-level implementation facilitation through structured visits. Results: In collaboration with the CP2CT Network and NCI, the DECC’s achievements span four domains: (1) Administrative: built infrastructure, deployed centralized reporting platforms, coordinated key meetings, and strengthened community integration. (2) Data: standardized collection, secured network-wide data sharing through the DTA, enabled harmonized multi-site reporting, and advanced groundwork for interoperability and scientific value. (3) Program Evaluation: linked CP2CT activities to measurable outcomes through a Network-wide Logic Model, guided evaluation, established shared evaluation language, and launched a transferable Process Evaluation framework. (4) Learning Collaborative: developed a centralized resource hub, expanded the Speaker Series, and advanced authorship transparency with the CP2CT Publication Policy. Conclusion: The CP2CT DECC has established a sustainable, scalable infrastructure that integrates administrative coordination, standardized data collection, robust program evaluation, and a collaborative learning environment. These efforts enhance clinical trial awareness, optimize referral pathways, and provide a transferable model for improving participant enrollment and scientific rigor across national research networks, ultimately addressing disparities in cancer outcomes. Citation Format: Laura E. Lectora, Cristina J. Orozco, Holly A. Thorson, Timethia Bonner, Robert R. Freimuth, Jennifer G. Le-Rademacher, Folakemi T. Odedina. Building a national network coordination center for clinical trials: Early implementation outcomes from the CP2CT DECC abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 899.

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