What question did this study set out to answer?

This research aims to improve the consistency of thyroid function test results across different testing platforms.

April 6, 2026

Harmonization of thyroid function test measurements across multiple immunoassay platforms for a common reference interval

GCGyu Won ChoKyung Hee University Hospital at Gangdong MKMin-Jeong KIMSookmyung Women's University MLMin Young LeeSungshin Women's University

Key Points

This research aims to improve the consistency of thyroid function test results across different testing platforms.
Utilized percentile transformation and regression-based recalibration methods for harmonization.
Focused on thyrotropin and FT4 reference intervals across various immunoassay platforms.
Assessed the limitations of T3 harmonization.
Achieved practical and cost-effective harmonization for thyrotropin and FT4.
Demonstrated clinical value by improving the consistency of interpretations for thyroid function tests.
Limited success in T3 harmonization was noted.

Abstract

Percentile transformation with regression-based recalibration enables practical and cost-effective harmonization of thyrotropin and FT4 reference intervals. Although T3 harmonization remained limited, this approach demonstrates the feasibility and clinical value of harmonized common reference intervals for improving interpretive consistency in thyroid function tests.

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