What question did this study set out to answer?

To report a fatal case of acute liver failure induced by N,N-Dimethylacetamide exposure in a young male worker.

April 6, 2026Open Access

N,N-Dimethylacetamide exposure induced-acute liver failure

Key Points

To report a fatal case of acute liver failure induced by N,N-Dimethylacetamide exposure in a young male worker.
Case presentation of a 30-year-old man who died after DMAC exposure.
Monitoring of workplace DMAC levels to assess inhalation risk.
Assessment of dermal absorption as a potential exposure route.
The patient developed acute liver failure after 5 days of DMAC exposure.
Exposure was primarily through inhalation but dermal absorption was suspected.
The case highlights the severe consequences of short-term DMAC exposure.

Abstract

This study aimed to share the case caused by N,N-Dimethylacetamide (DMAC) exposure. We report a 30-year-old man who died from DMAC exposure-induced acute liver failure after working in the cutting and cleansing of hollow fibre membranes for 5 days. While he was exposed to low-level DMAC by inhalation as the measurement of periodic working environment monitoring, considering his working method, considerable DMAC exposure via dermal absorption was suspected. Therefore, short-term, short-latency DMAC exposure via dermal absorption can cause fatal acute liver failure owing to idiosyncratic reactions.

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