Objective: To test whether selection bias has affected the reported effect estimate for the use of nicotine patches (RD 0.03. 95%CI: -0.03 to 0.09), regarding smoking cessation during pregnancy. Method: Trial adjusted, simulated comparator trial (SCT) based I2 test for single randomised controlled trials Result: The estimated selection bias level (B%) of 20% suggests that 11-20% (45 – 81 of 402) of the total trial subjects were non-randomly allocated in favour of one treatment group above the other. This level appears not high enough in order to have affected the reported effect estimate Conclusion: The effect estimate reported by the tested trial suggests a non-significantly higher smoking cessation rate in the nicotine patches group during pregnancy in comparison to placebo. The selection bias level, estimated by use of the trial adjusted, simulated comparator trial (SCT) based I2 test for single RCTs, B% = 20%, appears not high enough in order to have affected the reported estimate.
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Steffen Mickenautsch
Rotordynamics-Seal Research (United States)
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Steffen Mickenautsch (Mon,) studied this question.
www.synapsesocial.com/papers/69d894ce6c1944d70ce05baa — DOI: https://doi.org/10.17613/0287d-csz64