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HLRP #141: Neurodegenerative Routing Architecture — Geometric Coupling Theory | Synapse

April 10, 2026Open Access

HLRP #141: Neurodegenerative Routing Architecture — Geometric Coupling Theory

Key Points

The aim is to explore how neurodegenerative diseases are linked through failures in neuronal routing architectures.
Extend the Pituitary Relay Station model to neurodegenerative diseases
Identify common geometric coupling principles across disorders
Analyze breakdowns in neuronal routing architectures
Multiple sclerosis, Parkinson's disease, and ALS show similarities in relay station failures
Unified principles of geometric coupling apply to different neurodegenerative conditions
Breakdowns affect distinct neuronal routing architectures

Abstract

This paper extends the Pituitary Relay Station model (HLRP #140) to the neurodegenerative domain. We propose that multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis all represent relay station breakdowns in distinct neuronal routing architectures, unified by the same geometric coupling principles that govern pituitary failure.

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Authors

J

James E. Dunn

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Oldham Council

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Cite this study

James E. Dunn (Tue,) studied this question.

www.synapsesocial.com/papers/69d895046c1944d70ce05fa9 — DOI: https://doi.org/10.5281/zenodo.19462365