What question did this study set out to answer?

The aim is to assess how the timing of acellular dermal matrix (ADM) placement influences capsular contracture and complications in breast reconstruction.

April 10, 2026

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Timing of Acellular Dermal Matrix Placement in Two-stage Breast Reconstruction: Effects on Contracture and Complications

JLJ LiuYonsei University EYEunjung YangYonsei University SSSeung Yong SongYonsei University

Key Points

The aim is to assess how the timing of acellular dermal matrix (ADM) placement influences capsular contracture and complications in breast reconstruction.
Analyzed timing of ADM during two-stage breast reconstruction.
Evaluated outcomes like capsular contracture and seroma occurrences.
Considered the impact of radiotherapy and axillary surgery on complications.
Deferring ADM placement reduced the rates of capsular contracture.
No increase in expander loss was observed.
Higher seroma risk was noted in patients undergoing radiotherapy and/or axillary surgery.

Abstract

In prepectoral two-stage reconstruction, deferring ADM to the implant-exchange stage may reduce capsular contracture without increasing expander loss. Because seroma risk may be higher in patients receiving radiotherapy and/or axillary surgery, ADM timing should be individualized and paired with seroma-mitigation strategies in higher-risk patients.

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Timing of Acellular Dermal Matrix Placement in Two-stage Breast Reconstruction: Effects on Contracture and Complications

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