What question did this study set out to answer?

To explore the patterns and causes of cytotoxic lesions in the corpus callosum using MRI analysis.

April 11, 2026Open Access

Cytotoxic Lesions of the Corpus Callosum Patterns and Etiologies: Insights from an Indian Cohort

SBSagar BadachiSt.John's Medical College Hospital SSSonia ShivdeSt.John's Medical College Hospital SDSaikanth DeepalamSri Ramachandra Institute of Higher Education and Research

Key Points

To explore the patterns and causes of cytotoxic lesions in the corpus callosum using MRI analysis.
Analyzed MRI brain patterns for cytotoxic lesions in an Indian cohort
Identified patterns from isolated splenium involvement to broader extracallosal sites
Related MRI findings to potential etiologies for lesions
Identified varied MRI patterns of cytotoxic lesions in the corpus callosum
Patterns indicate a range of underlying causes
Variations suggest implications for clinical management and diagnosis

Abstract

CLOCCs is a clinicoradiological syndrome resulting from a wide variety of causes. MRI brain patterns can range from isolated involvement of the splenium to involvement of extracallosal sites, and these patterns may help identify the probable etiologies.

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