Pedagogical Use of Responsible Generative AI in Higher Education; Opportunities and Challenges: A Systematic Literature Review

Generative Artificial Intelligence (GenAI) is transforming higher education in terms of pedagogy, student involvement, and academic management. This systematic literature review examines 30 peer-reviewed articles published from 2019 to 2025, adhering to PRISMA 2020 and Kitchenham’s methodologies. Descriptive and thematic analyses highlight five opportunities: (a) tailored and adaptive education; (b) deliberate fostering of critical thinking; (c) enhanced accessibility for varied learners; (d) teaching innovation via multimodal content development and feedback; and (e) collaborative methods that regard AI as a co-teacher. Four ongoing challenge categories also surface: (a) risks to academic integrity; (b) excessive dependence on GenAI that may hinder learner independence; (c) inconsistent faculty preparedness and change-management abilities; and (d) differences in infrastructure and policy both regionally and globally. Intersecting ethical issues, such as data privacy, algorithmic bias, transparency, and accountability, highlight the necessity for governance that aligns with institutional risk and reflects societal values. Analyzing the recent literature, this systematic review offers four contributions: (a) a recommendation model for responsible GenAI implementation in higher education institutions; (b) a framework for sustainable integration of GenAI; (c) a highlight of the future research recommendations; and (d) an integrated policy and pedagogical recommendations roadmap. These models emphasize the integration of AI literacy, ethical considerations, and critical thinking goals into educational programs. The review advocates for a strategic, stakeholder-focused approach to implementation that enhances rather than replaces human instruction, thus connecting GenAI’s educational potential with ethical, context-aware avenues for institutional transformation.