Phytotherapeutics and Novel Approaches towards Treatment of Psoriasis –A Systematic Review

Introduction: Psoriasis is a long-term, immune-mediated skin condition marked by aberrant keratinocyte differentiation and hyperproliferation, which results in the development of red, scaly plaques. It affects 2–3% of people worldwide and has a major negative influence on a patient's social, psychological, and physical health Methods: Collection of information is from various sites, i.e. PubMed, Google Scholar, SciFinder, Research Gate and Medline Plus Results: Plants were employed due to their abundant chemoprotective and anticarcinogenic properties. The Th17 route and cytokines like IL-17, IL-23, and TNF-α have been implicated in the pathogenesis of psoriasis, according to recent developments in our understanding of the condition. Scientists are looking at alternative delivery mechanisms because conventional topical therapy approaches are non-specific, ineffective, and linked to lower side effects. The manuscript is a compilation of 227 articles only. Discussion: The treatment of psoriasis has undergone a revolution towards targeted and novel medicines, which provide safer and more effective alternatives to systemic therapy. Extremely hydrophobic drugs can be made more soluble by using nanoparticles. They improve the stability of medications while delivering a steady and regulated release. Higher medication concentrations can be delivered to specific regions via nanoparticles. It will also go over the difficulties and potential paths for psoriasis research, highlighting the importance of tailored treatment plans and a deeper comprehension of the underlying causes of the condition. Conclusion: This review presents a thorough summary of the state of the art regarding the aetiology, clinical symptoms, epidemiology, and available treatments for psoriasis, especially on plants and their novel approaches.