Background: Retinoids are established as a cornerstone in the management of photoaging; however, their clinical utility is frequently limited by local irritation, leading to poor patient compliance. This study evaluates the efficacy and safety of a new retinol formulation designed to improve skin texture and wrinkles while minimizing adverse effects. Methods: A prospective, rater-blinded pilot clinical study was conducted involving 21 women with moderate-to-severe photoaging over a 180-day period. Participants followed a progressive application protocol using a specific retinol emulsion alternating with a replenishing cream. Efficacy was assessed using the validated Rao–Goldman scale and VISIA® image analysis, while safety was monitored through the reporting of adverse events (AEs) and dermatological evaluations. The primary endpoint was the percentage of patients achieving a Rao–Goldman score of 2 at day 180. Results: A statistically significant improvement on the Rao–Goldman scale was observed, with 76.2% of patients improving from their baseline classification to exhibit only fine wrinkles (Grade 2) (p = 0.028). Instrumental analysis was performed using the VISIA® system. Regarding safety, although 81% of participants initially reported adverse effects such as erythema and scaling, these incidents decreased significantly over time. Conclusions: The novel retinol formulation demonstrates significant clinical efficacy in ameliorating the signs of photoaging, while maintaining a favorable safety profile
Llamas‐Velasco et al. (Thu,) studied this question.