Abstract LB231: Intra-pancreatic adipocytes promote pancreatic cancer progression by inhibiting tumor immunity

Abstract INTRODUCTION: Fatty pancreas diseases (FPD) is the most common disease of the pancreas. It is reported that FPD might be an early specific harbinger of pancreatic cancer. Pancreatic cancer is a highly lethal malignant tumor, and surgical resection remains the only possible curative treatment. The efficacy of other treatment modalities including immunotherapy is limited, making it urgent to explore novel therapeutic targets. Pancreatic cancer is characterized by a unique tumor microenvironment, where infiltrated adipocytes are closely associated with tumor progression. Albeit, the underlying mechanisms remain unclear. RATIONALE: This study aims to demonstrate why adipocyte prefer to deposit in pancreatic cancer tissue and how it contribute to the progression of pancreatic cancer. RESULTS: Using MRI imaging analysis (n=120) and H Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts) ; 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86 (8Suppl): Abstract nr LB231.