The silkworm ( Bombyx mori ), a key economic insect, plays a dual role in providing essential raw materials for silk production and serving as a model organism for genetic and biological research. In recent years, significant strides have been made in the understanding of silkworm diseases, driven by advances in molecular biology, genomics, and pathology. Silkworm diseases are typically classified into viral, bacterial, fungal, and parasitic categories, with nuclear polyhedrosis virus (BmNPV), cytoplasmic polyhedrosis virus (BmCPV), and microsporidia ( Nosema bombycis ) being the most prevalent. These diseases not only hinder silkworm growth and development but also compromise cocoon quality, leading to substantial economic losses in the sericulture industry. Current research has focused on the molecular mechanisms underlying silkworm diseases, evolutionary traits of pathogens, and their interactions with hosts. Genomic and transcriptomic studies have shed light on the regulatory mechanisms of disease resistance genes in silkworms and the molecular pathways involved in pathogen infection. Additionally, modern biotechnological innovations, such as diagnostic tools, biological control, and gene-editing technologies, have opened new avenues for controlling and preventing silkworm diseases. This review provides an overview of recent advancements in silkworm disease research and discusses potential future directions in this field.
Zhang et al. (Wed,) studied this question.
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