La Profilee (LP) derives the persistence condition IR = R/(F·M·K) <= 1 from three conditions: distinguishability (M1), real transformation (M2), and determinability of persistence (M3). This paper establishes what follows from the minimality of these conditions. M1-M3 are not empirical assumptions about this world. They are the minimal conditions under which the question "does this system remain the same system?" can have a determinate answer. No subset of them is sufficient. None can be replaced by something weaker. Together they are the minimal sufficient set for the persistence question to be well-posed. Wherever persistence is a meaningful concept, M1-M3 hold. Wherever M1-M3 hold, IR <= 1 is forced. LP therefore does not operate within a chosen descriptive regime. It operates at the level of conditions for persistence to be thinkable at all.
Marc Maibom (Sat,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: