What question did this study set out to answer?

To evaluate the effectiveness and challenges of FLOT chemotherapy in patients with resectable gastric adenocarcinoma.

April 22, 20260 citations

Perioperative FLOT Chemotherapy in Resectable Gastric Adenocarcinoma: A Single-center Retrospective Observational Study.

HNHemasireesha Natti VGVishesh Gumdal DKDeepak Koppaka

Key Points

To evaluate the effectiveness and challenges of FLOT chemotherapy in patients with resectable gastric adenocarcinoma.
Conducted a retrospective observational study at a single center
Analyzed surgical resection rates and treatment adherence
Evaluated the safety profile of FLOT chemotherapy
FLOT chemotherapy resulted in a lower-than-expected surgical resection rate
High attrition rates indicated challenges in treatment adherence
Need for improved patient selection strategies was emphasized

Abstract

While FLOT demonstrated an acceptable safety profile, the lower-than-expected surgical resection rate and high attrition highlight the challenges in managing locally advanced gastric cancer in real-world settings. This study emphasizes the need for strategies to improve treatment adherence and optimize patient selection to maximize the benefits of perioperative chemotherapy for gastric cancer.

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