Oncology nursing is one of healthcare’s most emotionally demanding specialties, characterized by sustained exposure to patient suffering and mortality. While global burnout rates reach 40–60%, emotional intelligence (EI) is a potential protective resource that remains underexamined in Middle Eastern contexts. Despite growing global evidence, little is known about these relationships in Middle Eastern healthcare systems, where cultural norms and workforce structures may shape emotional processes differently. This study examined whether EI was significantly associated with lower burnout across personal, work-related, and client-related dimensions among oncology nurses in Saudi Arabia. Methods: A cross-sectional correlational study enrolled 172 oncology nurses from three tertiary hospitals in Riyadh. Participants completed validated Arabic versions of the Schutte Self-Report Emotional Intelligence Test (SSEIT) and the Copenhagen Burnout Inventory (CBI). Hierarchical regression analyses examined predictive relationships while controlling for age and experience. Results: EI demonstrated significant inverse correlations with personal (r = −0.41), work-related (r = −0.38), and client-related burnout (r = −0.33, p < 0.001). In hierarchical models, EI emerged as a significant predictor of lower scores across all dimensions, explaining 11–17% of unique variance beyond demographic factors. The strongest association was with personal burnout. Causality cannot be inferred from this cross-sectional design. Conclusion: EI functions as a significant protective factor against burnout. Healthcare organizations should integrate EI development into professional training to strengthen workforce resilience and sustain care quality.
Alodhailah et al. (Mon,) studied this question.